서울대 장미숙 교수팀, 유전자 조작 없이 지방줄기세포 분화 유도 성공, <국민일보>, 2017. 11. 07 21:30
지방세포에서 뽑은 줄기세포로 정신질환 치료한다, <서울신문>, 2017. 11. 07 15:20
유전자 조작없이 지방줄기세포, 신경줄기세포로 세계 첫 전환, <디지털타임스>, 2017. 11. 07 10:04
유전자 조작 없이 '지방줄기세포→신경줄기세포' 전환 성공, <연합뉴스>, 2017. 11. 07 10:00
Hwang M, Song S, Chang MS*, Koh SH*. Glia-Like Cells from Human Mesenchymal Stem Cells Protect Neural Stem Cells in an in vitro Model of Alzheimer’s Disease by Reducing NLRP-3 Inflammasome. Dementia and Neurocognitive Disorders. 20(1):1-8. (pISSN: 1738-1495, eISSN 2384-0757) 2021.01. *Co-corresponding author
Lee J, Chang MS. Role of DARPP-32 in the Proliferation and Survival of Human Neural Stem Cells. The Korean Journal of Oral Anatomy. 41(1)97-108. (ISSN : 1225–6803) 2020.12.31. doi: 10.35607/kjoa.41.1.202012.009
Son JW, Park J, Kim YE, Ha J, Park DW, Chang MS*, Koh SH*. Glia-like cells from late-passage human MSCs protect against ischemic stroke through IGFBP-4. Mol. Neurobiol. 56:7617-7630, 2019.05.12. *Co-corresponding author
Park HW, Oh S, Lee KH, Lee BH, Chang MS. Olig2-expressing Mesenchymal Stem Cells Enhance Functional Recovery after Contusive Spinal Cord Injury. Int. J. Stem Cells. 11(2):177–186, 2018.10.
Jeon HJ, Park J, Shin JH, Chang MS. Insulin-like growth factor binding protein-6 released from human mesenchymal stem cells confers neuronal protection through IGF-1R-mediated signaling. Int. J. Mol. Med. 40(6):1860-1868, 2017.12.
Park J, Lee N, Lee J, Choe EK, Kim MK, Lee J, Byun MS, Chon MW, Kim SW, C. Justin Lee, Kim JH, Kwon JS, Chang MS. Small molecule-based lineage switch of human adipose-derived stem cells into neural stem cells and functional GABAergic neurons. Scientific Reports. 7(1):10166, 2017.08.
Shin JH, Jeon HJ, Park JH, Chang MS. Epigallocatechin-3-gallate prevents oxidative stress-induced cellular senescence in human mesenchymal stem cells via Nrf2. Int. J. Mol. Med. 38(4):1075-1082, 2016.10.
Park HW, Jeon HJ, Chang MS. Vascular endothelial growth factor enhances axonal outgrowth in organotypic spinal cord slices via vascular endothelial growth factor receptor 1 and 2. Tissue Engineering Regen. Med. 13(5):601-609, 2016.10.
Chang MS, Yoo JH, Woo DH and Chun MS. Efficient detection of Escherichia coli O157:H7 using a reusable microfluidic chip embedded with antimicrobial peptide-labeled beads. Analyst. 140(23):7997-8006, 2015.12.07.!divAbstract
Jung H, Chun MS*, Chang MS*. Sorting of human mesenchymal stem cells by applying optimally designed microfluidic chip filtration. Analyst. 140(4):1265-1274, 2015.02.21. *Co-corresponding author!divAbstract
Jung H, Shin JH, Park YS, and Chang MS. Ankyrin repeat-rich membrane spanning (ARMS)/Kidins220 scaffold protein regulates neuroblastoma cell proliferation through p21. Molecules and Cells. 37(12):881-887, 2014. 12. 31.
Yoo JH, Woo DH, Chang MS*, Chun MS*. Microfluidic based biosensing for Escherichia coli detection by embedding antimicrobial peptide-labeled beads. Sensors and Actuators B 191:211– 218, 2014.02. * Co-corresponding author
Lee EJ, Park HW, Jeon HJ, Kim HS*, Chang MS*. Potentiated therapeutic angiogenesis by primed human mesenchymal stem cells in a mouse model of hindlimb ischemia. Regenerative Medicine. 8(3):283-293, 2013.05.08. * Co-corresponding author
Yang ST, Kim HK, Lim YS, Chang MS, Lee SP, Park YS. A three dimensional observation of palatal vault growth in children using mixed effect analysis: a 9 year longitudinal study. European J. Orthodontics 35:832–840, 2013.
Park HW, Cho JS, Park CK, Jung SJ, Park CH, Lee SJ, Oh SB, Park YS, Chang MS. Directed induction of functional motor neuron-like cells from genetically engineered human mesenchymal stem cells. PLoS ONE 7(4): e35244, 2012.04.05.
Park YS, Chang MS, Lee SP. Three dimensional topography of the gingival line of young adult maxillary teeth: curve averaging using reverse-engineering methods. Int. J. Oral & Maxillofacial Implants 26(6):1217-1224, 2011.
Yoon EH, Lee KJ, Kim YS, Chang MS, Lee SH, Park CH. Retinoid X receptor  acts as a negative regulator in Nurr1-induced dopaminergic differentiation in rat neural precursor cells. Neuroreport 21(18):1162-1166, 2010.12.
Kim IS, Paik KS, Chang MS, Lee SP. The effect of differential modulation of the N-methyl-D-aspartate receptor on growth and intracellular calcium ion concentration in normal human oral keratinocytes. Tissue Engineering Regen. Med. 7(5):489-500, 2010.10.
Park HJ, Park HW, Lee SJ, Arevalo JC, Park YS, Lee SP, Paik KS, Chao MV, Chang MS. Ankyrin repeat-rich membrane spanning/Kidins220 protein interacts with mammalian Septin 5. Mol. Cells 30(2):143-148, 2010.08.
Park HW, Lim MJ, Jung H, Lee SP, Paik KS, Chang MS. Human mesenchymal stem cell-derived Schwann cell-like cells exhibit neurotrophic effects, via distinct growth factor production, in a model of spinal cord injury. Glia. 58(9):1118-1132, 2010.07.;jsessionid=B6DB9714660DFDD2E5770A8096B10FFD.f02t02
Oh S, Park HW, Cho JS, Jung H, Lee SP, Paik KS, Chang MS. Induction of a neuronal phenotype from human bone marrow-derived mesenchymal stem cells. Int. J. Oral Biol. 34(4):177-183, 2009.12.
Cho JS, Park HW, Park SK, Roh S, Kang SK, Paik KS, Chang MS. Transplantation of mesenchymal stem cells enhances axonal outgrowth and cell survival in an organotypic spinal cord slice culture. Neurosci. Lett. 454(1):43-48, 2009.04.
Lee Y, Yu JH, Cho JS, Park HJ, Lee SP, Paik KS, Chang MS. Interaction between the p75 neurotrophin receptor and a novel adaptor protein. Int. J. Oral Biol. 33(2):71-76, 2008.06.
Sauvageot C, Dahia PL, Lipan O, Park JK, Chang MS, Alberta JA, Stiles CD. Distinct temporal genetic signatures of neurogenic and gliogenic cues in cortical stem cell cultures. J. Neurobiol. 62(1):121-133, 2005.01.
Chang MS, Arevalo JC, Chao MV. Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein. J. Neurosci. Res. 78(2):186-192, 2004.10.
Chang MS, Sved AF, Zigmond MJ, and Austin MC. Increased transcription of the tyrosine hydroxylase gene in individual locus coeruleus neurons following footshock stress. Neuroscience. 101(1): 131-139, 2000.10.
Chang MS, Hahn MK., Sved AF, Zigmond MJ, Austin MC and Sherman TG. Analysis of tyrosine hydroxylase gene transcription using an intron specific probe. J. Neuroscience Methods. 94(2): 177-185, 2000.01.
Composition and method for differentiation of neural stem cells, neurons and GABAergic neurons from mesenchymal stem cells, United States, No. 10,280,399, 2019.05.07.
Neuronal regeneration material screening method by ex vivo model, United States, No. 7,947,435, 2011.05.24.
Differentiation method of adipose-derived mesenchymal stem cells into neural stem cells, neural cells, and GABAergic neural cells, Republic of Korea, No. 10-1870240-0000, 2018.06.18.
A composition for treating disease caused by neuronal insult comprising Schwann cell-like cells that secreting high amount of growth factors as active ingredients, Republic of Korea, No. 10-1147412-0000, 2012.05.11.
Method for inducing differentiation of human mesenchymal stem cells into motor neurons, Republic of Korea, No. 10-0973324-0000, 2010.07.26.
Neuronal regeneration material screening method by ex vivo model, Republic of Korea, No. 10-0930221-0000, 2009.11.30.
Method of inducing differentiation of mesenchymal stem cells into neurons, Republic of Korea, No. 10-0890992-0000, 2009.03.23.
연구목표는 저분자 화합물과 신경성장인자 등 신호전달
물질이나 분화관련 유전자를 도입하는 방법 등을 이용하여..
Mi-Sook Chang, DDS, PhD

Laboratory of Stem Cell and Neurobiology
Department of Oral Anatomy
School of Dentistry and Dental Research Institute
Seoul National University
Small molecule-based lineage switch of human adipose-derived stem cells into neural stem cells and functional GABAergic neurons
서울대학교 대학원 치의과학과 Laboratory of Stem cell & Neurobiology
[03080] 서울시 종로구 대학로 101(연건동) 서울대학교 치의학대학원 03080 생체재료동(신관) 602호 / TEL: 02-740-8629 / E-mail:
Copyright Laboratory of Stem Cell & Neurobiology,. All Rights Reserved.